When taking vitamin D3, it’s important to also get enough vitamin K2 because the two nutrients work together to support proper calcium metabolism in the body. Here’s why:
Vitamin D3 increases calcium absorption from the gut into the bloodstream.
Vitamin K2 activates proteins (like osteocalcin and matrix GLA) that help direct calcium into the bones and teeth—and keep it out of soft tissues like arteries and kidneys
Without enough K2, the extra calcium absorbed from D3 can accumulate in blood vessels, potentially contributing to arterial plaque and increasing cardiovascular risk.
K2 helps prevent calcium buildup in arteries by activating MGP (matrix Gla protein), which inhibits calcification.
D3 helps with calcium uptake, while K2 helps bind it to the bone matrix, making both crucial for preventing osteoporosis and maintaining strong bones.
Taking vitamin D3 without K2 can lead to calcium being misdirected. When taken together, they promote bone strength and cardiovascular protection.